反应详情

A 21.5 g (0.25 mole) portion of 2-imidazolidinone in 250 ml of dimethylsulfoxide was treated with 34.5 (0.25 mole) of K2CO3, 20.0 g (0.12 mole) of KI and 58.5 g (0.25 mole) of 4-benzyloxybenzyl chloride. The reaction mixture was heated to 105° over 0.5 hours, held at 105°-110° for 1.7 hours, poured with stirring into 1.5 l of H2O, stirred for 0.3 hours and filtered. The green-yellow solid was washed with 300 ml of H2O, air dried overnight, and dried to a constant weight at 60°, m.p. 110°-122°. Yield: 62 g (87%). Recrystallization from 1:1 methane: water gave an analytical sample, m.p. 156°-157°.

1. temperatureThe reaction mixture was heated to 105° over 0.5 hours
2. additionpoured
3. filtrationfiltered
4. washThe green-yellow solid was washed with 300 ml of H2O, air
5. customdried overnight
6. customdried to a constant weight at 60°
7. customRecrystallization from 1:1 methane
8. customwater gave an analytical sample, m.p. 156°-157°