D-Tartaric acid → HCID 86732925, compound

HRID 1580139Notes

Reaction equation

HRID 1580139 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]23[CH2:16][CH:13]([NH:14][CH2:15]2)[CH2:12][CH2:11][CH2:10]3)[CH:6]=[CH:7][CH:8]=1.[C:17]([OH:26])(=[O:25])[C@H:18]([C@@H:20]([C:22]([OH:24])=[O:23])[OH:21])[OH:19]>C(O)C>[C:17]([OH:26])(=[O:25])[C@H:18]([C@@H:20]([C:22]([OH:24])=[O:23])[OH:21])[OH:19].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]23[CH2:16][CH:13]([NH:14][CH2:15]2)[CH2:12][CH2:11][CH2:10]3)[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 439655D-Tartaric acidHCID 3045729HCID 3045729, compound

Product 1

HCID 86732925HCID 86732925, compoundYield 38.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

8.7 g of 1-(3-methoxyphenyl)-6-azabicyclo[3,2,1]octane and 6.2 g of d-tartaric acid are added to 80 ml of boiling-ethanol. The mixture is allowed to stand overnight. The crystalline precipitate is collected by filtration and then recrystallized from methanol. 5.65 g of (-)-1-(3-methoxyphenyl)-6-azabicyclo[3,2,1]octane d-tartarate are obtained. M.p. 190° - 192°C.

Workup

  1. filtrationThe crystalline precipitate is collected by filtration
  2. customrecrystallized from methanol

Sources & evidence

ORD record
ord-04b5fb453d424ba5a6a1bc2394adb4d7
Source dataset
uspto-grants-1976_01
Patent number
US03932429

Reaction notes

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