4-Chlorobenzaldehyde → HCID 2795077, compound

HRID 1580154Notes

Reaction equation

HRID 1580154 reaction equation
Br[CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:11].[Cl:12][C:13]1[CH:20]=[CH:19][C:16]([CH:17]=[O:18])=[CH:15][CH:14]=1.C[O-].[Na+]>CO>[Cl:12][C:13]1[CH:20]=[CH:19][C:16]([CH:17]2[O:18][C:2]32[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]3=[O:11])=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 77264-ChlorobenzaldehydeHCID 1372032-Bromo-1-indanoneHCID 10942334Sodium Methoxide

Product 1

HCID 2795077HCID 2795077, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a stirred solution of 2-bromo indanone and 5 g. of p-chloro-benzaldehyde in 20 ml of methanol under nitrogen is added at 5° to 10°C a solution of sodium methoxide in methanol (prepared by dissolving 1.15 g. of sodium in 50 ml of methanol). After 2 hours, 3'-(p-chlorophenyl)-spiro[indan-2,2'-oxirane]-1-one precipitates and is filtered off and recrystallized from methanol.

Workup

  1. custom3'-(p-chlorophenyl)-spiro[indan-2,2'-oxirane]-1-one precipitates
  2. filtrationis filtered off
  3. customrecrystallized from methanol

Sources & evidence

ORD record
ord-a42c244fee304664a874553c821c5ce4
Source dataset
uspto-grants-1976_01
Patent number
US03932430

Reaction notes

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