HRID1580164

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3776

Isopropanol

C3H8O

HCID66918

3-Chloropropyl(diethyl)amine

C7H16ClN

结构：CCn1c2ccc(C(=O)O)cc2c2cc(C(=O)O)ccc21

HCID3797914

9-ethyl-9H-carbazole-3,6-dicarboxylic acid

C16H13NO4

PRODUCTS

生成物

结构：CCN(CC)CCCOC(=O)c1ccc2c(c1)c1cc(C(=O)OCCCN(CC)CC)ccc1n2CC.Cl.Cl

HCID12331707

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID5963

Benzyltrimethylammonium chloride

C10H16ClN

溶剂HCID3283

Diethyl Ether

C4H10O

PROCEDURE

实验过程

To 250 ml. of isopropanol was added 10.0 g. (0.035 mole) of 9-ethylcarbazole-3,6-dicarboxylic acid, 21.2 g. (0.14 mole) of 3-diethylaminopropylchloride and 0.5 ml. of 60% aqueous benzyltrimethylammonium chloride. The solution was heated at reflux for 2 hours with stirring and then allowed to stir overnight at room temperature. Addition of ether to the reaction mixture gave the crystalline product which was recrystallized twice from methanol-acetone, m.p. 233°-234°, λmaxEtOH 252, E1 cm1% 865.

WORKUP

后处理

temperatureThe solution was heated
temperatureat reflux for 2 hours
stirringto stir overnight at room temperature
customgave the crystalline product which
customwas recrystallized twice from methanol-acetone, m.p. 233°-234°, λmaxEtOH 252, E1 cm1% 865

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9ac0d308e32140a2ab9deff1902bcb74
来源数据集: uspto-grants-1976_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US03932456
来源说明: uspto-grants-1976_01

反应 SMILES

[CH:1](O)([CH3:3])[CH3:2].[CH2:5]([N:7]1[C:19]2[CH:18]=[CH:17][C:16]([C:20]([OH:22])=[O:21])=[CH:15][C:14]=2[C:13]2[C:8]1=[CH:9][CH:10]=[C:11]([C:23]([OH:25])=[O:24])[CH:12]=2)[CH3:6].[CH2:26]([N:28]([CH2:33][CH3:34])[CH2:29][CH2:30][CH2:31][Cl:32])[CH3:27]>[Cl-].C([N+](C)(C)C)C1C=CC=CC=1.CCOCC>[ClH:32].[ClH:32].[CH2:5]([N:7]1[C:19]2[CH:18]=[CH:17][C:16]([C:20]([O:22][CH2:2][CH2:1][CH2:3][N:7]([CH2:8][CH3:9])[CH2:5][CH3:6])=[O:21])=[CH:15][C:14]=2[C:13]2[C:8]1=[CH:9][CH:10]=[C:11]([C:23]([O:25][CH2:31][CH2:30][CH2:29][N:28]([CH2:33][CH3:34])[CH2:26][CH3:27])=[O:24])[CH:12]=2)[CH3:6]