Trifluoroacetic acid → HCID 68134509, compound

HRID 1580510Notes

Reaction equation

HRID 1580510 reaction equation
C1(C([O:14][C:15]([C:17]2[N:22]3[C:23](=[O:35])[C@@H:24]([NH:25][C:26](=[O:34])[CH2:27][C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[C@H:21]3[S:20](=[O:36])[CH2:19][C:18]=2[CH2:37][C:38]2[O:42][C:41]([C:43]([O:45]C(C3C=CC=CC=3)C3C=CC=CC=3)=[O:44])=[CH:40][CH:39]=2)=[O:16])C2C=CC=CC=2)C=CC=CC=1.FC(F)(F)C(O)=O.C1(OC)C=CC=CC=1>>[C:43]([C:41]1[O:42][C:38]([CH2:37][C:18]2[CH2:19][S:20](=[O:36])[C@@H:21]3[C@H:24]([NH:25][C:26](=[O:34])[CH2:27][C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[C:23](=[O:35])[N:22]3[C:17]=2[C:15]([OH:16])=[O:14])=[CH:39][CH:40]=1)([OH:45])=[O:44]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 68133867HCID 68133867, compound

Product 1

HCID 68134509HCID 68134509, compound

Procedure

By treating 0.70 g of 3-(5-diphenylmethoxycarbonylfurfuryl)-7β-phenylacetylamino-ceph-3-em-4-carboxylic acid diphenylmethyl ester 1-oxide with 5 ml of trifluoroacetic acid and 2 ml of anisole, the 3-(5-carboxy-furfuryl)-7β-phenylacetylamino-ceph-3-em-4-carboxylic acid 1-oxide is obtained; thin-layer chromatogram (silica gel): Rf = 0.15 (system: n-butanol/ethanol/water 40:10:50).

Sources & evidence

ORD record
ord-9680b96f8a7e44d3b7acfa71861cfe51
Source dataset
uspto-grants-1976_01
Patent number
US03932465

Reaction notes

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