Hydroxyamine hydrochloride → HCID 53891326, compound

HRID 1580718Notes

Reaction equation

HRID 1580718 reaction equation
Cl.[NH2:2][OH:3].C([O-])(=O)C.[Na+].[Cl:9][C:10]1[CH:29]=[CH:28][CH:27]=[CH:26][C:11]=1[CH2:12][N:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:15]([CH2:22][C:23](=O)[CH3:24])=[CH:14]1>O.C(O)C>[Cl:9][C:10]1[CH:29]=[CH:28][CH:27]=[CH:26][C:11]=1[CH2:12][N:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:15]([CH2:22][C:23](=[N:2][OH:3])[CH3:24])=[CH:14]1

Participants

6

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 21563767HCID 21563767, compound

Product 1

HCID 53891326HCID 53891326, compoundYield 79%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

2.5 G of hydroxylamine hydrochloride and 2.5 g of sodium acetate dissolved in 10 ml of water are added to 2 g (0.023 mole) of 1-(2-chlorobenzyl)-3-(2-oxopropyl)indole dissolved in 100 ml of 96% ethyl alcohol. Stirring takes place for 12 hours at 20° and the oxime formed is filtered. The product is recrystallised from di-isopropyl ether.

Workup

  1. customfor 12 hours
  2. customat 20°

Sources & evidence

ORD record
ord-630d8f420b9f4c66a4955f3386d2da5d
Source dataset
uspto-grants-1976_01
Patent number
US03933853

Reaction notes

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