Hydrochloric Acid → Phenol, 2-(diethoxymethyl)-

HRID 1580723Notes

Reaction equation

HRID 1580723 reaction equation
[CH:1](=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4].[CH2:10]([O:12]C(O)O)[CH3:11].Cl.[CH2:17](O)[CH3:18]>>[CH2:17]([O:9][CH:1]([O:12][CH2:10][CH3:11])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4])[CH3:18]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 6998SalicylaldehydeHCID 5231668Orthoameisensaureathylester

Product 1

HCID 11356048Phenol, 2-(diethoxymethyl)-

Procedure

A mixture of 122 parts of salicylaldehyde, 180 parts of orthoformic acid ethyl ester and 120 parts of anhydrous ethanol was mixed with 1 ml of concentrated hydrochloric acid, whereupon the whole heated up spontaneously. After a short time, the solution was heated to the boil and then evaporated under vacuum, and the residue distilled under a high vacuum. The product passed over at 80°C under 0.15mm Hg pressure.

Workup

  1. temperatureheated up spontaneously
  2. temperatureAfter a short time, the solution was heated to the boil
  3. customevaporated under vacuum
  4. distillationthe residue distilled under a high vacuum
  5. custompassed over at 80°C under 0.15mm Hg pressure

Sources & evidence

ORD record
ord-11b165ad0bc14f2a98a947048166ebb0
Source dataset
uspto-grants-1976_01
Patent number
US03933858

Reaction notes

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