Hydrogen Peroxide → HCID 21561684, compound

HRID 1581148Notes

Reaction equation

HRID 1581148 reaction equation
[ClH:1].Cl.[Cl:3][C:4]1[CH:18]=[CH:17][C:7]2[N:8]=[C:9]([NH:11][C:12]3[NH:13][CH2:14][CH2:15][N:16]=3)[NH:10][C:6]=2[CH:5]=1.OO>Cl>[ClH:3].[Cl:3][C:4]1[C:18]([Cl:1])=[CH:17][C:7]2[N:8]=[C:9]([NH:11][C:12]3[NH:13][CH2:14][CH2:15][N:16]=3)[NH:10][C:6]=2[CH:5]=1

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 131710019HCID 131710019, compound

Product 1

HCID 21561684HCID 21561684, compoundYield 30%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
80 °C

Procedure

2-(5-Choro-2-benzimidazolyl) amino-2-imidazoline dihydrochloride (3.1g, 0.01 mol) in concentrated hydrochloric acid (25 ml) was treated with hydrogen peroxide (10%, 3.4ml) then heated to 80°C, maintained at this temperature for 15 minutes and then allowed to cool to room temperature. Recrystalisation of the resulting precipitate from water gave 2-(5,6-dichlorobenzimidazolyl) amino-2-imidazoline hydrochloride (0.46g, 15%) m.p. 279°-281°C.

Workup

  1. temperaturemaintained at this temperature for 15 minutes
  2. temperatureto cool to room temperature
  3. customRecrystalisation of the resulting precipitate from water

Sources & evidence

ORD record
ord-69b2b0df56424e93b89641b78093df96
Source dataset
uspto-grants-1976_01
Patent number
US03935314

Reaction notes

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