Hydrochloric Acid → 6-Oxo-1,6-dihydro-pyridazine-3-sulfonic Acid methyl-phenyl-amide

HRID 1581495노트

반응식

HRID 1581495 반응식
[CH3:1][N:2]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[S:3]([C:6]1[N:7]=[N:8][C:9]([O:12]C)=[CH:10][CH:11]=1)(=[O:5])=[O:4].Cl>O1CCOCC1>[CH3:1][N:2]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[S:3]([C:6]1[CH:11]=[CH:10][C:9](=[O:12])[NH:8][N:7]=1)(=[O:4])=[O:5]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 697035156-Methoxy-pyridazine-3-sulfonic acid methyl-phenyl-amide

생성물 1

HCID 98784626-Oxo-1,6-dihydro-pyridazine-3-sulfonic Acid methyl-phenyl-amide수율 75.3%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A mixture of 6-methoxy-pyridazine-3-sulfonic acid methyl-phenyl-amide (239 mg), dioxane (4 mL) and concentrated hydrochloric acid (1 mL) was prepared and refluxed for one hour. The mixture was then evaporated to dryness. The resulting solid was triturated with water and the solid was collected to afford the title compound (75%, 171 mg); mp, 157-158° C.

후처리

  1. customwas prepared
  2. temperaturerefluxed for one hour
  3. customThe mixture was then evaporated to dryness
  4. customThe resulting solid was triturated with water
  5. customthe solid was collected

출처 및 근거

ORD 기록
ord-75ae6dbbced34545acbdde82355e2aa5
출처 데이터셋
uspto-grants-2004_05
특허 번호
US06730674B2

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