反应详情

Triethylamine (12 mmol), DMAP (0.6 mmol), and succinic anhydride (9 mmol) are added to a solution of 5-nitrotryptamine (6 mmol) in dichloromethane (25 mL). The mixture is stirred 4 h, the solvent removed in vacuo, and the residue chromatographed on silica gel using 10% methanol-chloroform with 1% acetic acid as eluent. The product is then hydrogenated and transformed to the carbamic acid methyl ester as in the previous examples. Purified product is obtained by reverse-phase HPLC as above.

1. customthe solvent removed in vacuo
2. customthe residue chromatographed on silica gel using 10% methanol-chloroform with 1% acetic acid as eluent
3. customPurified product is obtained by reverse-phase HPLC as above