Hydrochloric Acid → HCID 12992850, compound

HRID 1581835Notes

Reaction equation

HRID 1581835 reaction equation
[C:1]([C:3]([CH3:16])([CH3:15])[C:4](=[O:14])[CH:5]([CH3:13])[C:6]([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7])#[N:2].[BH4-].[Na+].Cl.C(=O)([O-])O.[Na+]>CO>[C:1]([C:3]([CH3:15])([CH3:16])[CH:4]([OH:14])[CH:5]([CH3:13])[C:6]([O:8][C:9]([CH3:11])([CH3:10])[CH3:12])=[O:7])#[N:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 4311764Sodium borohydrideHCID 12992849HCID 12992849, compound

Product 1

HCID 12992850HCID 12992850, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

tert-Butyl 4-cyano-2,4-dimethyl-3-oxopentanoate (400 mg, 1.775 mmol) obtained in Example 12 was diluted with methanol (5 mL) and cooled to 0° C. Sodium borohydride (20 mg, 0.53 mmol) was added. The mixture was stirred at 0° C. for 10 min and 10% aqueous hydrochloric acid solution (0.5 mL) was added. The mixture was further stirred for 10 min. Aqueous saturated sodium hydrogencarbonate solution (2 mL) was added and the mixture was further stirred for 10 min.

Workup

  1. stirringThe mixture was further stirred for 10 min
  2. stirringthe mixture was further stirred for 10 min.

Sources & evidence

ORD record
ord-7d31ed0f7c54428a8a5ad3f8c274bcc3
Source dataset
uspto-grants-2004_05
Patent number
US06730803B2

Reaction notes

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