Ammonia → N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-3-sulfamoylphenylsulfonamide

HRID 1581925Notes

Reaction equation

HRID 1581925 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[N:9]2[CH2:12][CH:11]([NH2:13])[CH2:10]2)=[CH:4][CH:3]=1.[C:21]1([S:31](Cl)(=[O:33])=[O:32])[CH:26]=[CH:25][CH:24]=[C:23]([S:27](Cl)(=[O:29])=[O:28])[CH:22]=1.C([N:37](CC)CC)C.N>C(#N)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[N:9]2[CH2:10][CH:11]([NH:13][S:31]([C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([S:27](=[O:29])(=[O:28])[NH2:37])[CH:22]=3)(=[O:33])=[O:32])[CH2:12]2)=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 222AmmoniaHCID 8471TriethylamineHCID 962401,3-Benzenedisulfonyl dichlorideHCID 218965981-[Bis(4-chlorophenyl)methyl]azetidin-3-ylamine

Product 1

HCID 15521569N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-3-sulfamoylphenylsulfonamide

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 0.307 g of 1-[bis(4-chlorophenyl)methyl]azetidin-3-ylamine is added dropwise, at room temperature, to a solution of 0.412 g of 1,3-benzenedisulfonic acid dichloride and 0.165 cm3 of triethylamine in 10 cm3 of acetonitrile. After stirring for 3 hours at room temperature, 0.28 cm3 of a 20% solution of ammonia is added and the reaction mixture is left at room temperature. After 18 hours, the mixture is filtered and concentrated to dryness under reduced pressure (2.7 kPa). After chromatography on a silica gel column (particle size 0.06-0.200 mm, height 35 cm, diameter 2 cm), eluting under an argon pressure of 0.9 bar with dichloromethane and then a mixture of dichloromethane+1% methanol and then a mixture of dichloromethane+2% methanol by volume and collecting 30-cm3 fractions, fractions 23 to 34 are combined and concentrated to dryness under reduced pressure (2.7 kPa) to give 90 mg of N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-3-sulfamoylphenylsulfonamide in the form of a white solid [1H NMR spectrum (300 MHz, CDCl3, δ in ppm): 2.78 (broad t, J=7 Hz: 2H); 3.35 (broad t, J=7 Hz: 2H); 4.01 (mt: 1H); 4.24 (s: 1H); 5.27 (unresolved complex: 2H); 5.61 (unresolved complex: 1H); from 7.15 to 7.35 (mt: 8H); 7.67 (t, J=8 Hz: 1H); 8.04 (broad d, J=8 Hz: 1H); 8.12 (broad d, J=8 Hz: 1H); 8.49 (broad s: 1H)].

Workup

  1. waitthe reaction mixture is left at room temperature
  2. waitAfter 18 hours
  3. filtrationthe mixture is filtered
  4. concentrationconcentrated to dryness under reduced pressure (2.7 kPa)
  5. washAfter chromatography on a silica gel column (particle size 0.06-0.200 mm, height 35 cm, diameter 2 cm), eluting under an argon pressure of 0.9 bar with dichloromethane
  6. additiona mixture of dichloromethane+1% methanol
  7. additiona mixture of dichloromethane+2% methanol by volume
  8. customcollecting 30-cm3 fractions, fractions 23 to 34
  9. concentrationconcentrated to dryness under reduced pressure (2.7 kPa)

Sources & evidence

ORD record
ord-50432945e03a46fbb0ac9692562e58e3
Source dataset
uspto-grants-2004_05
Patent number
US06734176B2

Reaction notes

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