Methyl morpholine oxide → 1-(6-Isopropyl-4,4-dimethyl-1-n-propyl-1,2,3,4-tetrahydro-quinolin-8-yl)-ethanone

HRID 1582086Notes

Reaction equation

HRID 1582086 reaction equation
[CH2:1]([N:4]1[C:13]2[C:8](=[CH:9][C:10]([CH:17]([CH3:19])[CH3:18])=[CH:11][C:12]=2[CH:14]([OH:16])[CH3:15])[C:7]([CH3:21])([CH3:20])[CH2:6][CH2:5]1)[CH2:2][CH3:3].C[N+]1([O-])CCOCC1>>[CH:17]([C:10]1[CH:9]=[C:8]2[C:13](=[C:12]([C:14](=[O:16])[CH3:15])[CH:11]=1)[N:4]([CH2:1][CH2:2][CH3:3])[CH2:5][CH2:6][C:7]2([CH3:21])[CH3:20])([CH3:18])[CH3:19]

Participants

3

Reactant 2

HCID 82029Methyl morpholine oxideHCID 227198211-(6-Isopropyl-4,4-dimethyl-1-n-propyl-1,2,3,4-tetrahydro-quinolin-8-yl)-ethanol2×

Product 1

HCID 227198321-(6-Isopropyl-4,4-dimethyl-1-n-propyl-1,2,3,4-tetrahydro-quinolin-8-yl)-ethanone

Procedure

Following General Procedure D, 1-(1-n-propyl-6-isopropyl-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-8-yl)-ethan-1-ol (Intermediate 11, 4.54 g, 18.1 mmol) and 4-methylmorpholine N-oxide (4.23 g, 36.2 mmol) were reacted to give the title compound as a yellow oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-845573d89c5f4978af956fca7b35d7fe
Source dataset
uspto-grants-2004_05
Patent number
US06734193B1

Reaction notes

Loading…