反应详情

温度

40 °C

To a solution of 1,1-dimethylethyl 4-(2-methyl-5-quinolinyl)-1-piperazinecarboxylate in 2-propanol (3 vol) was added dropwise hydrochloric acid (37%, 3 vol). The mixture was stirred at 40° C. for 1.5 hours then concentrated. Water (30 vol) was added and the solution was extracted with ethyl acetate (3×20 vol). The aqueous layer was basified with an aqueous sodium carbonate solution then extracted with dichloromethane (5×40 vol). The combined organic extracts were dried and evaporated to give the title compound as an off-white solid (80% th, 2 steps).

1. concentrationthen concentrated
2. additionWater (30 vol) was added
3. extractionthe solution was extracted with ethyl acetate (3×20 vol)
4. extractionthen extracted with dichloromethane (5×40 vol)
5. customThe combined organic extracts were dried
6. customevaporated