Sodium Formate → HCID 10659637, compound

HRID 1582427Notes

Reaction equation

HRID 1582427 reaction equation
C([O:8][C@H:9]1[C@@H:13]2[O:14][CH2:15][C@@:10]1([CH2:25][OH:26])[O:11][C@H:12]2[N:16]1[CH:24]=[C:22]([CH3:23])[C:20](=[O:21])[NH:19][C:17]1=[O:18])C1C=CC=CC=1.C([O-])=O.[Na+]>CO.[Pd]>[OH:8][C@H:9]1[C@@H:13]2[O:14][CH2:15][C@@:10]1([CH2:25][OH:26])[O:11][C@H:12]2[N:16]1[CH:24]=[C:22]([CH3:23])[C:20](=[O:21])[NH:19][C:17]1=[O:18]

Participants

5

Reactant 2

HCID 2723810Sodium FormateHCID 10760979HCID 10760979, compound

Product 1

HCID 10659637HCID 10659637, compoundYield 96%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of compound 11 (750 mg, 2.09 mmol) and 10% Pd/C (500 mg) was suspended in methanol (20 mL) and sodium formate (700 mg, 11.1 mmol) was added. The reaction was conducted at refluxing for 10 min and cooled to ambient temperature. The catalyst was filtered off and the mixture was concentrated under reduced pressure to give compound 12 (540 mg, 96%) as a white solid material.

Workup

  1. temperatureat refluxing for 10 min
  2. filtrationThe catalyst was filtered off
  3. concentrationthe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-bfc8b7a1cc17420385860008bd5fb16b
Source dataset
uspto-grants-2004_05
Patent number
US06734291B2

Reaction notes

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