Water → HCID 22717653, compound

HRID 1582535Notes

Reaction equation

HRID 1582535 reaction equation
[CH2:1]([CH:3]1[C:12]2[CH:11]=[C:10]3[NH:13][C:14](=O)[CH:15]=[C:16]([OH:17])[C:9]3=[CH:8][C:7]=2[NH:6][CH2:5][CH2:4]1)[CH3:2].[OH-].[K+].S([O:26][CH3:27])(OC)(=O)=O.O.[CH3:29]N(C)C=O>>[CH2:1]([CH:3]1[C:12]2[CH:11]=[C:10]3[N:13]([CH3:14])[C:27](=[O:26])[CH:15]=[C:16]([O:17][CH3:29])[C:9]3=[CH:8][C:7]=2[NH:6][CH2:5][CH2:4]1)[CH3:2]

Participants

6

Reactant 5

HCID 962WaterHCID 6228DimethylformamideHCID 6497Dimethyl SulfateHCID 14797Potassium HydroxideHCID 69864680HCID 69864680, compound

Product 1

HCID 22717653HCID 22717653, compound

Procedure

2 g (8.2 mmol) of 9-ethyl-4-hydroxy-6,7,8,9-tetrahydro-1H-pyrido[2,3-g]quinol-2-one are suspended in 25 ml of dimethylformamide and treated with 6.7 g (0.12 mol) of potassium hydroxide. 8.6 g (0.07 mol) of dimethyl sulfate are added dropwise thereto at at most 60° C. (cooling with ice/sodium chloride bath). The suspension is discharged into 200 ml of water. A well filterable precipitate is formed, which is filtered off with suction and dried.

Workup

  1. customA well filterable precipitate is formed
  2. filtrationwhich is filtered off with suction
  3. customdried

Sources & evidence

ORD record
ord-bd5e7d021a9044da879d4efa5a0b8bc5
Source dataset
uspto-grants-2004_05
Patent number
US06737280B1

Reaction notes

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