Methylamine → HCID 22718383, compound

HRID 1582580Notes

Reaction equation

HRID 1582580 reaction equation
[C:1]1([S:7]([C:10]([NH:14][C:15](=[O:22])[C:16]2[CH:21]=[CH:20][CH:19]=[N:18][CH:17]=2)=[C:11](Cl)Cl)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:23][NH2:24]>O1CCCC1>[C:1]1([S:7]([C:10]2[N:14]=[C:15]([C:16]3[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=3)[O:22][C:11]=2[CH2:23][NH2:24])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 11462457HCID 11462457, compound

Product 1

HCID 22718383HCID 22718383, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

N-(1-Phenylsulfonyl-2,2-dichlorovinyl)nicotinamide (0.4 g, 1.120 mmol) is dissolved in tetrahydrofuran, mixed with methylamine (2.607 ml, 2M in tetrahydrofuran, 4.480 mmol) and stirred overnight at room temperature. The resulting precipitate was filtered off with suction and discarded, the mother liquor was concentrated in a rotary evaporator and the residue was crystallized using a small amount of isopropanol, filtered off with suction and dried in air.

Workup

  1. filtrationThe resulting precipitate was filtered off with suction
  2. concentrationthe mother liquor was concentrated in a rotary evaporator
  3. customthe residue was crystallized
  4. filtrationfiltered off with suction
  5. customdried in air

Sources & evidence

ORD record
ord-cc6406e0c23440788f48583a05bbdb54
Source dataset
uspto-grants-2004_05
Patent number
US06737426B1

Reaction notes

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