huagongshe.com
HRID15826

反应详情

EQUATION

反应方程式

HRID 15826 的结构方程式

REACTANTS

反应物

4
结构：On1nnc2ccccc21
HCID75771

1-Hydroxybenzotriazole

C6H5N3O

结构：CCN=C=NCCCN(C)C.Cl
HCID2723939

1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

C8H18ClN3

结构：O=C(O)Cc1cccc(-n2cccn2)c1
HCID21062671

未命名化合物

结构：Cc1ccc2c(N3CCN(CCc4cccc(N)c4)CC3)cccc2n1
HCID49852105

未命名化合物

PRODUCTS

生成物

1
结构：Cc1ccc2c(N3CCN(C(=O)Cc4cccc(-n5cccn5)c4)CC3)cccc2n1
HCID49851260

未命名化合物

收率 74%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

EDC•HCl (1.5 eq), HOBt (2 eq) and 2-methyl-5-(1-piperazinyl)quinoline (D3) (1 eq) were added sequentially to a stirred solution of [3-(1H-pyrazol-1-yl)phenyl]acetic acid (D19) (1.1 eq) in dimethylformamide at room temperature under an inert atmosphere. The solvent was removed by means of an SCX cartridge. The crude material was purified on SPE cartridge (Silica) eluting with a gradient from dichloromethane/MeOH 99/1 to dichloromethane/MeOH 98/2 affording the title compound in 74% yield.

WORKUP

后处理

  1. customThe solvent was removed by means of an SCX cartridge
  2. customThe crude material was purified on SPE cartridge (Silica)
  3. washeluting with a gradient from dichloromethane/MeOH 99/1 to dichloromethane/MeOH 98/2 affording the title compound in 74% yield