Acetyl chloride → Ethyl 2-acetylamino-4-thiazoleacetate

HRID 1582959Notes

Reaction equation

HRID 1582959 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[C:13](Cl)(=[O:15])[CH3:14].C(N(CC)CC)C>ClC(Cl)C>[C:13]([NH:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1)(=[O:15])[CH3:14]

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl ester

Product 1

HCID 3477732Ethyl 2-acetylamino-4-thiazoleacetate

Reagents, catalysts & solvents 1

HCID 63651,1-DichloroethaneSolvent

Procedure

Ethyl 2-(2-aminothiazol-4-yl)acetate was reacted with acetyl chloride in dichloroethane in the presence of triethylamine, and then the reaction mixture was worked up and purified in a usual manner to obtain ethyl 2-(2-acetylaminothiazol-4-yl)acetate as a colorless solid. MS: 229.

Workup

  1. custompurified in a usual manner

Sources & evidence

ORD record
ord-5d306a3a912545939136f2066be05193
Source dataset
uspto-grants-2004_05
Patent number
US06740662B1

Reaction notes

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