Ethylamine → HCID 22716716, compound

HRID 1582964Notes

Reaction equation

HRID 1582964 reaction equation
Cl[C:2]1[C:7]([C:8](=[O:16])[C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([Cl:15])[CH:10]=2)=[CH:6][CH:5]=[C:4]([Cl:17])[N:3]=1.[CH2:18]([NH2:20])[CH3:19]>C1COCC1>[Cl:17][C:4]1[N:3]=[C:2]([NH:20][CH2:18][CH3:19])[C:7]([C:8](=[O:16])[C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([Cl:15])[CH:10]=2)=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 6341EthylamineHCID 22716658HCID 22716658, compound

Product 1

HCID 22716716HCID 22716716, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a THF solution of 2,6-dichloro-3-(3-chlorobenzoyl)pyridine was added a 70% ethylamine aqueous solution, followed by reaction at room temperature. Thereafter, the reaction mixture was worked up and purified in a usual manner to obtain 6-chloro-3-(3-chlorobenzoyl)-2-ethylaminopyridine. NMR1: 8.95 (1H, brs), 6.48 (1H, d, J=7.8 Hz), 1.31 (3H, t, J=7.1 Hz).

Workup

  1. customfollowed by reaction at room temperature
  2. custompurified in a usual manner

Sources & evidence

ORD record
ord-c926049fa5644d45bdccef36c2ccd9c0
Source dataset
uspto-grants-2004_05
Patent number
US06740662B1

Reaction notes

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