Iodoethane → HCID 18600046, compound

HRID 1583261Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH2:20][CH2:19][C@@:18]2([CH3:21])[C:5](=[CH:6][CH2:7][C@@H:8]3[C@@H:17]2[CH2:16][CH2:15][C@@:13]2([CH3:14])[C@H:9]3[CH2:10][CH2:11][C:12]2=[C:22]([N+:33]#[C-:34])[S:23]([C:26]2[CH:31]=[CH:30][C:29]([CH3:32])=[CH:28][CH:27]=2)(=[O:25])=[O:24])[CH:4]=1.[CH2:35](I)[CH3:36]>>[CH3:1][O:2][C:3]1[CH2:20][CH2:19][C@@:18]2([CH3:21])[C:5](=[CH:6][CH2:7][C@@H:8]3[C@@H:17]2[CH2:16][CH2:15][C@@:13]2([CH3:14])[C@H:9]3[CH2:10][CH:11]=[C:12]2[C:22]([N+:33]#[C-:34])([S:23]([C:26]2[CH:27]=[CH:28][C:29]([CH3:32])=[CH:30][CH:31]=2)(=[O:25])=[O:24])[CH2:35][CH3:36])[CH:4]=1

Participants

Reactant 2

HCID 6340Iodoethane

HCID 53955656HCID 53955656, compound

Product 1

HCID 18600046HCID 18600046, compound

Procedure

The title compound was prepared according to the method described in Example 8a starting from 3-methoxy-17-(isocyano-p-methylphenylsulfonylmethylene)-androsta-3,5-diene (954 mg, 2 mmol) and ethyl iodide (4.9 mmol). Yield: 900 mg (89%), m.p. 135°-150° C.

Sources & evidence

ORD record: ord-d6dff310875e4c0e8bb9ea71624454f7
Source dataset: uspto-grants-1985_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04551278

Reaction notes

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