Hydrochloric Acid → HCID 10882550, compound

HRID 1583262Notes

Reaction equation

HRID 1583262 reaction equation
C[O:2][C:3]1[CH2:34][CH2:33][C@@:32]2([CH3:35])[C:5](=[CH:6][CH2:7][C@@H:8]3[C@@H:31]2[CH2:30][CH2:29][C@@:28]2([CH3:36])[C@H:9]3[CH2:10][CH:11]=[C:12]2[C:13]([N+]#[C-])(S(C2C=CC(C)=CC=2)(=O)=O)[CH2:14]Cl)[CH:4]=1.[ClH:37].C([O:40]CC)C>C(Cl)Cl>[Cl:37][CH2:14][C:13](=[O:40])[C:12]1[C@:28]2([CH3:36])[C@H:9]([C@H:8]3[C@H:31]([CH2:30][CH2:29]2)[C@:32]2([CH3:35])[C:5](=[CH:4][C:3](=[O:2])[CH2:34][CH2:33]2)[CH2:6][CH2:7]3)[CH2:10][CH:11]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 18600042HCID 18600042, compound

Product 1

HCID 10882550HCID 10882550, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

The title compound was prepared by hydrolysis of the compound prepared in Example 15a in a mixture of methylene chloride (5 ml) and diethyl ether (25 ml). This mixture was stirred vigorously with hydrochloric acid (2 ml, 38%), for 5 minutes. After work up and chromatography (methylene chloride, alumina act. II-III) the title compound was obtained (55 mg, 15%).

Sources & evidence

ORD record
ord-e577995731f14c20a0317dbbf094c3c4
Source dataset
uspto-grants-1985_11
Patent number
US04551278

Reaction notes

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