3-Acetylpyridine → HCID 54180870, compound

HRID 1583391Notes

Reaction equation

HRID 1583391 reaction equation
[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=1)(=[O:3])[CH3:2].CO[C:12](OC)([N:14]([CH3:16])[CH3:15])[CH3:13]>>[CH3:15][N:14]([CH3:16])[C:12]([CH3:13])=[CH:2][C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=1)=[O:3]

Participants

3

Reactant 2

HCID 95893-AcetylpyridineHCID 878351,1-Dimethoxyethyl(dimethyl)amine

Product 1

HCID 54180870HCID 54180870, compound

Procedure

A mixture of 40.0 g of 3-acetylpyridine and 50.0 ml of dimethylacetamide dimethylacetal was heated on a steam bath for 6 hours under argon. The volatile components were then removed in vacuo and hexane was added to the resultant thick syrup to crystallize the product. Filtration gave 33.5 g of the desired product as red-brown crystals, mp 62°-64° C.

Workup

  1. temperaturewas heated on a steam bath for 6 hours under argon
  2. customThe volatile components were then removed in vacuo and hexane
  3. additionwas added to the resultant thick syrup
  4. customto crystallize the product
  5. filtrationFiltration

Sources & evidence

ORD record
ord-3dae5f4025444a48802a3714279c5232
Source dataset
uspto-grants-1985_11
Patent number
US04551530

Reaction notes

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