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HRID1583412

反应详情

EQUATION

反应方程式

HRID 1583412 的结构方程式

REACTANTS

反应物

1
结构：OCCCCC#Cc1cncnc1
HCID13999752

6-(Pyrimidin-5-yl)hex-5-yn-1-ol

C10H12N2O

PRODUCTS

生成物

1
结构：OCCCCCCc1cncnc1
HCID13557544

6-(Pyrimidin-5-yl)hexan-1-ol

C10H16N2O

收率 88.1%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Pd]
催化剂HCID23938

Palladium

Pd

结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

A solution of 25.3 g of 6-(5-pyrimidinyl)-5-hexyn-1-ol in 300 ml of isopropanol was hydrogenated over a total of 2.1 g of 10% palladium on carbon added in two portions. The residue was distilled to yield 22.8 g (88%) of 5-pyrimidinehexanol, bp 185°-196° C./0.35 mm.

WORKUP

后处理

  1. additionadded in two portions
  2. distillationThe residue was distilled