反应详情

温度

100 °C

A mixture of 4.0 g of potassium cyanide, 0.85 g of potassium iodide and 10.1 g of 6-(3-pyridyl)hexyl chloride in 100 ml of dimethylformamide was heated at 100° C. overnight. The reaction mixture was diluted with 200 ml of water and was extracted with dichloromethane. The combined organic layers were washed with water, dried over potassium carbonate and were evaporated. The residue was distilled to give 8.1 g (84%) of 3-pyridine heptanenitrile.

1. extractionwas extracted with dichloromethane
2. washThe combined organic layers were washed with water
3. dry with materialdried over potassium carbonate
4. customwere evaporated
5. distillationThe residue was distilled