反应详情

A stirred solution of 2.0 g (0.0114 mole) of trans-3-(2,2-difluoroethenyl)-2,2-dimethylcyclopropanecarboxylic acid and 0.08 g of N,N-dimethylformamide in 20 ml of dry diethyl ether was cooled to 0° C. A solution of 2.17 g (0.017 mole) of oxalyl chloride in 2 ml of dry diethyl ether was added to the reaction mixture during a 20 minute period. Upon complete addition the mixture was allowed to warm to room temperature and stirred for two hours. The mixture was concentrated under reduced pressure to give a yellow oil. The oil was dissolved in 5 ml of dry diethyl ether and the solvent removed under reduced pressure to yield trans-3-(2,2-difluoroethenyl)-2,2-dimethylcyclopropanecarbonyl chloride as an oil.

1. additionUpon complete addition the mixture
2. concentrationThe mixture was concentrated under reduced pressure
3. customto give a yellow oil
4. customthe solvent removed under reduced pressure