反应详情

A solution of 0.42 g. of methyl 5-ethoxy-6-hydroxybenzothiophene-2-carboxylate, 0.25 g. of potassium carbonate, a catalytic amount of potassium iodide, and 0.31 g. of propyl iodide in methyl ethyl ketone was heated to reflux for 48 hours. The hot solution was filtered and the filtrate was evaporated in vacuo to provide the desired subtitle intermediate which was used in the subsequent reaction without purification.

1. temperatureto reflux for 48 hours
2. filtrationThe hot solution was filtered
3. customthe filtrate was evaporated in vacuo