Potassium Iodide → HCID 20259226, compound

HRID 1583579Notes

Reaction equation

HRID 1583579 reaction equation
[CH2:1]([O:3][C:4]1[C:5]([OH:17])=[CH:6][C:7]2[S:11][C:10]([C:12]([O:14][CH3:15])=[O:13])=[CH:9][C:8]=2[CH:16]=1)[CH3:2].C(=O)([O-])[O-].[K+].[K+].[I-].[K+].[CH2:26](I)[CH2:27][CH3:28]>C(C(C)=O)C>[CH2:1]([O:3][C:4]1[C:5]([O:17][CH2:26][CH2:27][CH3:28])=[CH:6][C:7]2[S:11][C:10]([C:12]([O:14][CH3:15])=[O:13])=[CH:9][C:8]=2[CH:16]=1)[CH3:2]

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 336431-IodopropaneHCID 20259234Methyl 5-ethoxy-6-hydroxybenzo[b]thiophene-2-carboxylate

Product 1

HCID 20259226HCID 20259226, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

A solution of 0.42 g. of methyl 5-ethoxy-6-hydroxybenzothiophene-2-carboxylate, 0.25 g. of potassium carbonate, a catalytic amount of potassium iodide, and 0.31 g. of propyl iodide in methyl ethyl ketone was heated to reflux for 48 hours. The hot solution was filtered and the filtrate was evaporated in vacuo to provide the desired subtitle intermediate which was used in the subsequent reaction without purification.

Workup

  1. temperatureto reflux for 48 hours
  2. filtrationThe hot solution was filtered
  3. customthe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-7a6cf4d4cc7e4fba81ce8118bd420f1d
Source dataset
uspto-grants-1985_11
Patent number
US04552891

Reaction notes

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