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HRID1583725

反应详情

EQUATION

反应方程式

HRID 1583725 的结构方程式

REACTANTS

反应物

2
结构：O=C1CCCC(=O)O1
HCID7940

Glutaric anhydride

C5H6O3

结构：CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)N
HCID13750002

L-Alanyl-L-alanyl-N-ethyl-L-prolinamide

C13H24N4O3

PRODUCTS

生成物

1
结构：CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CCCC(=O)O
HCID13749988

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度
60 °C

PROCEDURE

实验过程

1.7 g of glutaric anhydride was added to a solution of 4.0 grams of alanyl-alanyl proline ethylamide in 25 ml of dimethylformamide and the reaction solution heated for 1 hour at 60 degrees C. Then, the solution was evaporated and the resultant non-crystalline evaporation residue dissolved in 30 ml of ethyl acetate. After 48 hours of standing at 3 degrees C., 3.6 g of separated product was filtered off with a melting point of 154 to 156 degrees C. ([α]D20 -137.3 degrees (c 0.3; 50% methyl alcohol).

WORKUP

后处理

  1. customThen, the solution was evaporated
  2. dissolutionthe resultant non-crystalline evaporation residue dissolved in 30 ml of ethyl acetate
  3. filtration, 3.6 g of separated product was filtered off with a melting point of 154 to 156 degrees C