Hydrochloric Acid → HCID 178500032, compound

HRID 1584250Notes

Reaction equation

HRID 1584250 reaction equation
[NH:1]1[CH:5]=[C:4](/[CH:6]=[CH:7]/[C:8]([OH:10])=[O:9])[N:3]=[CH:2]1.[ClH:11].[CH3:12]O>>[ClH:11].[CH3:12][O:9][C:8](=[O:10])/[CH:7]=[CH:6]/[C:4]1[N:3]=[CH:2][NH:1][CH:5]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 178525354HCID 178525354, compound

Product 1

HCID 178500032HCID 178500032, compound

Procedure

A solution of trans-4-imidazoleacrylic acid (20.0 g 145 mmol) in methanol (300 ml) was saturated with anhydrous HCl and the resulting solution was then refluxed for 90 min. After cooling to room temperature the solvent was removed in vacu to to give the title compound as a white solid: 1H NMR (CD3OD) d 3.80 (s, 3 H), 6.61 (d, J=16 Hz, 1 H), 7.60 (d, J=16 Hz, 1 H), 7.92, (s, 1 H), 9.05, (s, 1 H).

Workup

  1. temperaturethe resulting solution was then refluxed for 90 min
  2. customwas removed in vacu

Sources & evidence

ORD record
ord-3468d6618c6144bb9c4f68ce3d020421
Source dataset
uspto-grants-1999_08
Patent number
US05932606

Reaction notes

Loading…