Hydrochloric Acid → 1-(5-Methyl-2-phenyl-4-oxazolyl)ethanol

HRID 1584363Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1584363
[BH4-].[Na+].[C:3]([C:6]1[N:7]=[C:8]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[O:9][C:10]=1[CH3:11])(=[O:5])[CH3:4].O.Cl>C(O)C>[CH3:11][C:10]1[O:9][C:8]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:7][C:6]=1[CH:3]([OH:5])[CH3:4]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 4311764Sodium borohydrideHCID 123378491-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)ethan-1-one

Produkt 1

HCID 184738961-(5-Methyl-2-phenyl-4-oxazolyl)ethanolAusbeute 86 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Sodium borohydride (1.41 g) was added portionwise, at 0° C., to a solution of 4-acetyl-5-methyl-2-phenyloxazole (15.0 g) in ethanol (100 ml). The mixture was stirred for 1 hour at the same temperature, and then for 1 hour at room temperature. The reaction mixture was poured into water, which was neutralized with 2N HCl to obtain 1-(5-methyl-2-phenyl-4-oxazolyl)ethanol (13.0 g, 86%), which was recrystallized from ethyl acetate-hexane to give colorless prisms, m.p.101-102° C.

Aufarbeitung

  1. waitfor 1 hour at room temperature

Quellen und Nachweise

ORD-Eintrag
ord-9754b85edb944ca9a0e7a4ad49ee719a
Quelldatensatz
uspto-grants-1999_08
Patentnummer
US05932601

Notizen zur Reaktion

Wird geladen…