反应详情

Sodium borohydride (1.41 g) was added portionwise, at 0° C., to a solution of 4-acetyl-5-methyl-2-phenyloxazole (15.0 g) in ethanol (100 ml). The mixture was stirred for 1 hour at the same temperature, and then for 1 hour at room temperature. The reaction mixture was poured into water, which was neutralized with 2N HCl to obtain 1-(5-methyl-2-phenyl-4-oxazolyl)ethanol (13.0 g, 86%), which was recrystallized from ethyl acetate-hexane to give colorless prisms, m.p.101-102° C.

1. waitfor 1 hour at room temperature