Dichloromethane → HCID 86754354, compound

HRID 1584444Notes

Reaction equation

HRID 1584444 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[N:19]([CH2:20][CH2:21][CH2:22][CH2:23][C:24]#[N:25])[C:18]3[CH:26]=[CH:27][CH:28]=[CH:29][C:17]=3[N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.ClCCl.[IH:33]>C(OCC)C>[IH:33].[C:24]([CH2:23][CH2:22][CH2:21][CH2:20][N:19]1[C:18]2[CH:26]=[CH:27][CH:28]=[CH:29][C:17]=2[N:16]=[C:15]1[N:11]1[CH2:12][CH2:13][CH2:14][NH:8][CH2:9][CH2:10]1)#[N:25]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 24841Hydrogen iodideHCID 21223791HCID 21223791, compound

Product 1

HCID 86754354HCID 86754354, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
40 °C

Procedure

Combine 1-(t-butoxycarbonyl)-4-(1-(4-cyanobutyl)-1H-benzimidazol-2-yl)[1,4]diazepane (0.3 mmol) and dichloromethane (5 mL). Add aqueous 48% hydriodic acid solution (0.6 mmol). Heat to 40° C. After 6 hours, cool to ambient temperature dilute with diethyl ether (20 mL), and collect the solid to give the title compound.

Workup

  1. temperaturecool to ambient temperature
  2. customcollect the solid

Sources & evidence

ORD record
ord-8b45892fc0c44ef28d58f8799c74d6df
Source dataset
uspto-grants-1999_08
Patent number
US05932571

Reaction notes

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