反应详情

A mixture of 5-bromo-benzofuran-7-carbaldehyde (0.315 g), 1-methyl-5-tributylstannanyl-1H-[1,2,3]-triazole (0.525 g) and bis(triphenylphosphine)palladium (II) chloride (0.05 g) in toluene (7 ml) was stirred and refluxed under nitrogen for 5 h. The cooled mixture was diluted with 8% sodium bicarbonate (30 ml) and extracted with ethyl acetate (3×25 ml). The combined extracts were dried (MgSO4) and the solvent removed in vacuo to give a yellow solid (0.8 g). Purification by FCC, eluting with ethyl acetate-hexane, then ethyl acetate gave a cream solid, which was crystallised from ethyl acetate to give the title compound as pale green crystals (0.18 g), m.p. 180-2°.

1. temperaturerefluxed under nitrogen for 5 h
2. extractionextracted with ethyl acetate (3×25 ml)
3. dry with materialThe combined extracts were dried (MgSO4)
4. customthe solvent removed in vacuo