Potassium Carbonate → HCID 21220844, compound

HRID 1584797Notes

Reaction equation

HRID 1584797 reaction equation
FC(F)(F)C([NH:5][C:6]1[CH:7]=[C:8]([CH3:15])[C:9]2[O:13][CH:12]=[CH:11][C:10]=2[CH:14]=1)=O.C(=O)([O-])[O-].[K+].[K+]>CO.O>[NH2:5][C:6]1[CH:7]=[C:8]([CH3:15])[C:9]2[O:13][CH:12]=[CH:11][C:10]=2[CH:14]=1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 21220846HCID 21220846, compound

Product 1

HCID 21220844HCID 21220844, compoundYield 99.7%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A mixture of 2,2,2trifluoro-N-(7-methyl-benzofuran-5-yl)-acetamide (580 mg) and potassium carbonate (1.64 g) in methanol (25 ml) and water (2.5 ml) was heated at reflux for 2.5 hours. The residue was extracted with dichloromethane (3×25 ml) and the combined, dried (MgSO4) organic phase was evaporated in vacuo to give the title compound as a colourless oil (350 mg).

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 2.5 hours
  3. extractionThe residue was extracted with dichloromethane (3×25 ml)
  4. dry with materialdried (MgSO4) organic phase
  5. customwas evaporated in vacuo

Sources & evidence

ORD record
ord-93851e3da08348dab1c6c54cb96d3e51
Source dataset
uspto-grants-1999_08
Patent number
US05935972

Reaction notes

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