Triethylamine → HCID 178513436, compound

HRID 1585091Notes

Reaction equation

HRID 1585091 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]#[N:12])=[CH:6][CH:5]=1)([OH:3])=[O:2].Cl.[NH2:14][OH:15].C(N(CC)CC)C>CO>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([NH:10][C:11]([NH:14][OH:15])=[NH:12])=[CH:8][CH:9]=1)([OH:3])=[O:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 443297Hydroxyamine hydrochlorideHCID 129823264-CYANAMINOBENZOIC ACID

Product 1

HCID 178513436HCID 178513436, compoundYield 56.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 150 ml of methanol was dissolved 6.56 g of 4-carboxyphenyl cyanamide produced in Reference Example 26. To the solution were added, while stirring at room temperature, 6.1 g of hydroxylamine hydrochloride and 8.88 g of triethylamine. The mixture was stirred for two hours. The resulting crystalline precipitate was collected by filtration to afford 4.45 g of the title compound as a colorless crystalline product.

Workup

  1. customproduced in Reference Example 26
  2. additionTo the solution were added
  3. stirringThe mixture was stirred for two hours
  4. filtrationThe resulting crystalline precipitate was collected by filtration

Sources & evidence

ORD record
ord-e6e68cd1370d44149a46220cbf350dd9
Source dataset
uspto-grants-1999_08
Patent number
US05935963

Reaction notes

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