Hydrogen Peroxide → HCID 15435155, compound

HRID 1585572Notes

Reaction equation

HRID 1585572 reaction equation
[F:1][C:2]([F:24])([F:23])[C:3]1[CH:22]=[CH:21][C:6]([C:7]([N:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:12]=[CH:11][CH:10]2[C:19]#[N:20])=[O:8])=[CH:5][CH:4]=1.C(=O)(O)[O-:26].[Na+].OO>CC(C)=O>[F:24][C:2]([F:23])([F:1])[C:3]1[CH:4]=[CH:5][C:6]([C:7]([N:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:12]=[CH:11][CH:10]2[C:19]([NH2:20])=[O:26])=[O:8])=[CH:21][CH:22]=1

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 516892Sodium BicarbonateHCID 21219136HCID 21219136, compound

Product 1

HCID 15435155HCID 15435155, compoundYield 40.8%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The title compound was prepared by the procedure described in step 2 of Example 1 using 20.0 g of 1-(4-Trifluoromethylbenzoyl)-1,2-dihydro-quinoline-2-carbonitrile, 10.0 g of sodium bicarbonate, 500 mL of acetone, and 250 mL of 30% hydrogen peroxide solution. Crystallization from acetonitrile afforded the title compound (8.6 g) as a white solid, m. p. 158-160° C.

Workup

  1. customThe title compound was prepared by the procedure
  2. customCrystallization from acetonitrile

Sources & evidence

ORD record
ord-fbcce114c87d4ea7b67741bfc171b112
Source dataset
uspto-grants-1999_08
Patent number
US05939435

Reaction notes

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