Hydrazine hydrate (1:1) → 1-Hydrazino-2-methyl-4-nitrobenzene hydrofluoride

HRID 1585755Notes

Reaction equation

HRID 1585755 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[CH3:11].O.[NH2:13][NH2:14]>CC(O)C>[FH:1].[NH:13]([C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[CH3:11])[NH2:14]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)2×HCID 68001Benzene, 1-fluoro-2-methyl-4-nitro-

Product 1

HCID 221117871-Hydrazino-2-methyl-4-nitrobenzene hydrofluoride

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A mixture of 4.6 g of 1-fluoro-2-methyl-4-nitrobenzene and 3 ml of hydrazine hydrate in 45 ml of 2-propanol is heated to reflux for 2 hours. 3 ml of hydrazine hydrate are added, refluxing is continued for 2 hours and the mixture is left overnight with stirring at RT. The precipitate formed is drained. 3.53 g of the expected product are obtained, m.p.=182° C.

Workup

  1. temperatureis heated
  2. temperatureto reflux for 2 hours
  3. temperaturerefluxing
  4. waitthe mixture is left overnight
  5. customThe precipitate formed

Sources & evidence

ORD record
ord-87cdf8dd09a54a66b102dc849ff085e4
Source dataset
uspto-grants-1999_08
Patent number
US05939449

Reaction notes

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