Ammonia → HCID 86754417, compound

HRID 1585811Notes

Reaction equation

[ClH:1].C(O[C:5](=[NH:26])[C:6]1[CH:11]=[CH:10][C:9]([C@@:12]2([CH3:25])[C:16](=[O:17])[N:15]([CH2:18][C:19]([O:21][CH3:22])=[O:20])[C:14](=[O:23])[N:13]2[CH3:24])=[CH:8][CH:7]=1)C.[NH3:27].C(OCC)C>C(O)(C)C>[ClH:1].[NH2:27][C:5](=[NH:26])[C:6]1[CH:11]=[CH:10][C:9]([C@@:12]2([CH3:25])[C:16](=[O:17])[N:15]([CH2:18][C:19]([O:21][CH3:22])=[O:20])[C:14](=[O:23])[N:13]2[CH3:24])=[CH:8][CH:7]=1

Participants

Conditions

Temperature: 50 °C

Procedure

2.26 g of methyl (S)-(4-(4-(ethoxy-imino-methyl)phenyl)-3,4-dimethyl-2,5-dioxoimidazolidin-1-yl)acetate hydrochloride (6.4 mmol) were suspended in 25 ml of isopropanol and treated with 7.2 ml of a 2N solution of ammonia in isopropanol. The reaction mixture was stirred at 50° C. for 2.5 hours. The mixture was cooled and then treated with 200 ml of diethyl ether. The precipitate was filtered off with suction and dried in a high vacuum.

Workup

temperatureThe mixture was cooled
filtrationThe precipitate was filtered off with suction
customdried in a high vacuum

Sources & evidence

ORD record: ord-7213549a99c84a08991354ade0d771ff
Source dataset: uspto-grants-1999_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05939556

Reaction notes

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