反应详情

温度

80 °C

To a solution of the thiocarbonate from Step 4 (0.263 g, 0.386 mmol) in benzene (3 ml) at room temperature was added tributyl tin hydride (0.159 ml, 3.74 mmol) and AIBN (0.012 g, 0.50 mmol) and the mixture was heated at 80° C. for 3 hrs. The solvent was evaporated in vacuo. The residue was chromatographed (silica gel, MeOH: CH2Cl2 2:98 to 4:96 gradient elution) to afford the title compound.

1. customThe solvent was evaporated in vacuo
2. customThe residue was chromatographed
3. wash(silica gel, MeOH: CH2Cl2 2:98 to 4:96 gradient elution)