Allyl Mercaptan → 3-methoxy-6-allylthiopyridazine

HRID 1585987Notes

Reaction equation

HRID 1585987 reaction equation
[Na].[CH2:2]([SH:5])[CH:3]=[CH2:4].[CH3:6][O:7][C:8]1[N:9]=[N:10][C:11](Cl)=[CH:12][CH:13]=1>CO>[CH3:6][O:7][C:8]1[N:9]=[N:10][C:11]([S:5][CH2:2][CH:3]=[CH2:4])=[CH:12][CH:13]=1

Participants

5

Reactant 3

HCID 13367Allyl MercaptanHCID 744033-Chloro-6-methoxypyridazineHCID 5360545Sodium

Product 1

HCID 101302403-methoxy-6-allylthiopyridazine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.15 g(0.05 mol) of metallic sodium was dissolved in 50 ml of absolute methanol and then mixed with 4.98 ml(0.05 mol) of allylmercaptan. To this mixture was added 7.23 g(0.05 mol) of 3-methoxy-6-chloropyridazine. The reaction solution was refluxed for 24 hours and then treated according to the same manner as Example 1 to obtain the title compound as a freezing pale white crystal.

Workup

  1. temperatureThe reaction solution was refluxed for 24 hours
  2. additiontreated

Sources & evidence

ORD record
ord-839aba1b279b42b6986df30e72046d16
Source dataset
uspto-grants-1999_08
Patent number
US05942511

Reaction notes

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