Hydrochloric Acid → HCID 178516281, compound

HRID 1586061Notes

Reaction equation

HRID 1586061 reaction equation
[CH2:1]([O:8][CH2:9][C:10](=[N:17][C:18]1[CH:22]=[CH:21][NH:20][N:19]=1)[CH:11]1[CH2:15][CH2:14][O:13][C:12]1=[O:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.Cl>O>[CH2:1]([O:8][CH2:9][C:10]1[NH:17][C:18]2[N:19]([N:20]=[CH:21][CH:22]=2)[C:12](=[O:16])[C:11]=1[CH2:15][CH2:14][OH:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 178519082HCID 178519082, compound

Product 1

HCID 178516281HCID 178516281, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 1.18 g of 3-{[2-(benzyloxy)-1-(tetrahydro-2-oxo-3-furyl)ethylidene]amino}pyrazole were added 600 μl of triethylamine and 2.0 ml of water, and the mixture was stirred for 40 minutes while heating under reflux. After the reaction system was allowed to coom to room temperature, 1N hydrochloric acid was added to adjust the pH of the reaction mixture to 4. After the reaction mixture was extracted with chloroform, and the organic layer was dried over anhydrous sodium sulfate, the solvent was distilled off to obtain 1.18 g (yield: quantitative) of the intended product.

Workup

  1. temperaturewhile heating
  2. temperatureunder reflux
  3. customto coom to room temperature
  4. extractionAfter the reaction mixture was extracted with chloroform
  5. dry with materialthe organic layer was dried over anhydrous sodium sulfate
  6. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-bb0f8d67d6a84b3886e95fbcc9e6ab97
Source dataset
uspto-grants-1999_08
Patent number
US05942515

Reaction notes

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