反应详情

A mixture of 1H-Benzimidazole-5-nitrile, 2-(4-hydroxyphenyl)- (2.6 g, 0.011 mol), potassium carbonate (4.0 g, 0.029 mol), and 4-fluorobenzonitrile (1.2 g, 0.0099 mol) in DMF (100 mL) was refluxed for 18 h. The mixture was then filtered (to remove the potassium carbonate) into an ice/water bath. The precipitate was collected and recrystallized from ethyl acetate to afford 0.7 g (21%) of 2-[4-(4-cyanophenoxy)phenyl]-1H-benzimidazole-5-carbonitrile.

1. temperaturewas refluxed for 18 h
2. filtrationThe mixture was then filtered (
3. customto remove the potassium carbonate) into an ice/water bath
4. customThe precipitate was collected
5. customrecrystallized from ethyl acetate