反应详情

A solution of 5.00 g (0.033 mol) of t-butyl chloroacetate in 30 ml of DMF is run, dropwise and at room temperature, into a mixture of 7.62 g (0.030 mol) of 4-chloro-3-(3,5-dichlorophenyl)pyrazole and 5.60 g (0.040 mol) of K2CO3. The reaction mixture is stirred for 12 h at room temperature, diluted with 200 ml of H2O and extracted with ether. After drying the organic phase and concentration under vacuum, the residue is triturated with 20 ml of heptane, filtered and dried. We obtain 10.20 g of 1-t-butoxycarbonylmethyl-4-chloro-3-(3,5-dichlorophenyl)pyrazole, melting at 86° C.

1. extractionextracted with ether
2. customAfter drying
3. concentrationthe organic phase and concentration under vacuum
4. customthe residue is triturated with 20 ml of heptane
5. filtrationfiltered
6. customdried