1-(2-Hydroxyethyl)piperazine → 1-(4-Fluorobenzyl)-4-(2-Hydroxyethyl)Piperazine

HRID 1586447Notes

Reaction equation

HRID 1586447 reaction equation
[N:1]1([CH2:7][CH2:8][OH:9])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[F:10][C:11]1[CH:18]=[CH:17][C:14]([CH2:15]Cl)=[CH:13][CH:12]=1>>[F:10][C:11]1[CH:18]=[CH:17][C:14]([CH2:15][N:4]2[CH2:5][CH2:6][N:1]([CH2:7][CH2:8][OH:9])[CH2:2][CH2:3]2)=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 96024-Fluorobenzyl chloride

Product 1

HCID 6938071-(4-Fluorobenzyl)-4-(2-Hydroxyethyl)Piperazine

Procedure

The title compound was synthesized by using 2-(1-piperazinyl)ethanol and p-fluorobenzyl chloride according to the same process as in Preparation Example 4.

Workup

  1. customas in Preparation Example 4

Sources & evidence

ORD record
ord-82a9b5df5a42495785edb6ec9460517d
Source dataset
uspto-grants-1999_08
Patent number
US05945434

Reaction notes

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