反应详情

温度

70 °C

6,6'-Dimethyl-4-nitro-2,2'-bipyridine-N-oxide (17) (1.0 g, 4.1 mmoles) was added to sodium ethoxide solution made from (0.19 g, 0.0083 g-atoms) sodium and 25 ml ethanol. The mixture was stirred at 70° C. for 30 minutes. After neutralization with concentrated hydrochloric acid the reaction mixture was filtered and evaporated to dryness. The product was purified by means of flash chromatography (silica, 0%-50% methanol/chloroform).

1. filtrationAfter neutralization with concentrated hydrochloric acid the reaction mixture was filtered
2. customevaporated to dryness
3. customThe product was purified by means of flash chromatography (silica, 0%-50% methanol/chloroform)