HRID1587196

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10960

Glycol monoacetate

C4H8O3

HCID11776

Triphenylphosphine

C18H15P

结构：COc1ccc(CC(CN2CCN(C(=O)OCc3ccccc3)CC2)NS(=O)(=O)c2cccc3cnccc23)cc1

HCID19795884

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(CC(CN2CCN(C(=O)OCc3ccccc3)CC2)N(CCOC(C)=O)S(=O)(=O)c2cccc3cnccc23)cc1

HCID19796392

未命名化合物

收率 52.2%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

1.0 g of the product obtained in Example 73 was dissolved in 5 ml of tetrahydrofuran, to the solution were added 220 mg of ethylene glycol monoacetate and 685 mg of triphenylphosphine in place of N-tert-butoxycarbonylethanolamine, according to the procedure described :n Example 136, to obtain 600 mg of the title compound in a colorless amorphous form.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-01d2aa9bbc4846129b822b753ff5f06d
来源数据集: uspto-grants-1993_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05216150
来源说明: uspto-grants-1993_06

反应 SMILES

[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][N:14]([CH2:17][CH:18]([NH:28][S:29]([C:32]2[C:33]3[CH:34]=[CH:35][N:36]=[CH:37][C:38]=3[CH:39]=[CH:40][CH:41]=2)(=[O:31])=[O:30])[CH2:19][C:20]2[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=2)[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:42]([O:45][CH2:46][CH2:47]O)(=[O:44])[CH3:43].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>O1CCCC1>[C:42]([O:45][CH2:46][CH2:47][N:28]([CH:18]([CH2:19][C:20]1[CH:21]=[CH:22][C:23]([O:26][CH3:27])=[CH:24][CH:25]=1)[CH2:17][N:14]1[CH2:13][CH2:12][N:11]([C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[O:10])[CH2:16][CH2:15]1)[S:29]([C:32]1[C:33]2[CH:34]=[CH:35][N:36]=[CH:37][C:38]=2[CH:39]=[CH:40][CH:41]=1)(=[O:31])=[O:30])(=[O:44])[CH3:43]