Hydrogen Bromide → HCID 18652407, compound

HRID 1587484Notes

Reaction equation

HRID 1587484 reaction equation
[N:1]1([C:6]([CH2:8][N:9]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[C:13]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:12][C@@H:11]([NH:26]C(OC(C)C3C=CC=CC=3)=O)[C:10]2=[O:38])=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.[BrH:39]>C(Cl)Cl>[BrH:39].[N:1]1([C:6]([CH2:8][N:9]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[C:13]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:12][C@@H:11]([NH2:26])[C:10]2=[O:38])=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 18652406HCID 18652406, compound

Product 1

HCID 18652407HCID 18652407, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1,3-Dihydro-1-(pyrrolidinylcarbonyl)methyl-3(R){[(α-methyl)benzyloxy-carbonyl]-amino}-5-phenyl-2H-1,4-benzodiazepin-2-one (109 mg) was dissolved in 10 ml of dry methylene chloride. The solution was cooled to 0° C. and saturated with hydrogen bromide gas. After 30 minutes the solvent and excess hydrogen bromide were removed under reduced pressure to give 147 mg of the title compound as a pale yellow solid.

Workup

  1. customAfter 30 minutes the solvent and excess hydrogen bromide were removed under reduced pressure

Sources & evidence

ORD record
ord-c887419a494f4b49b9131092c63ec64b
Source dataset
uspto-grants-1993_06
Patent number
US05218115

Reaction notes

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