Hydrochloric Acid → HCID 131717973, compound

HRID 1587584Notes

Reaction equation

HRID 1587584 reaction equation
[OH:1][N:2]([CH3:31])[C:3](=[O:30])[CH:4]([CH3:29])[C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19]3[N:23]([CH3:24])[C:22]4[CH:25]=[CH:26][CH:27]=[CH:28][C:21]=4[N:20]=3)=[CH:13][CH:12]=2)=[CH:7][CH:6]=1.[ClH:32]>CO.C(OCC)C>[ClH:32].[OH:1][N:2]([CH3:31])[C:3](=[O:30])[CH:4]([CH3:29])[C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[CH:13][C:14]([O:17][CH2:18][C:19]3[N:23]([CH3:24])[C:22]4[CH:25]=[CH:26][CH:27]=[CH:28][C:21]=4[N:20]=3)=[CH:15][CH:16]=2)=[CH:7][CH:6]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 18956570HCID 18956570, compound

Product 1

HCID 131717973HCID 131717973, compoundYield 92.2%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

A solution containing N-hydroxy-N,α-dimethyl-4'-[(1-methyl-1H-benzimidazol-2-yl)methoxy]-[1,1'-biphenyl]-4-acetamide (0.2 g, 0.48 mmol) in warm methanol (100 mL) is treated with 1M hydrogen chloride in diethyl ether (3 mL). The solution is concentrated under reduced pressure to a solid residue. This material is crystallized from a mixture of ethanol and diethyl ether to give 0.2 g (92.2%) of white crystalline product, m.p. 131° C. (dec.).

Workup

  1. concentrationThe solution is concentrated under reduced pressure to a solid residue
  2. customThis material is crystallized from a mixture of ethanol and diethyl ether

Sources & evidence

ORD record
ord-a705cbdd5b8b459581c3a04e9e9a1b4e
Source dataset
uspto-grants-1993_06
Patent number
US05218124

Reaction notes

Loading…