3-Acetylpyridine → HCID 57395319, compound

HRID 1587751Notes

Reaction equation

HRID 1587751 reaction equation
Cl.[O:2]([NH2:4])[CH3:3].[C:5]([C:8]1[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=1)(=O)[CH3:6].C(=O)([O-])[O-].[K+].[K+]>CO.O>[CH3:3][O:2][N:4]=[C:5]([C:8]1[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=1)[CH3:6]

Participants

6

Reactant 3

HCID 95893-AcetylpyridineHCID 11430Potassium CarbonateHCID 521874O-Methylhydroxylamine hydrochloride

Product 1

HCID 57395319HCID 57395319, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

6.85 g of methoxylamine hydrochloride is added to 10 g of 3-acetyl pyridine in 50 cm3 of methanol and the whole is heated to reflux for 3 hours. The solvent is eliminated under reduced pressure, the residue is taken up in water, alkanlized with potassium carbonate and extracted with ethyl acetate. After evaporating, 11 g of the expected product is recovered. (b.p.: 115°-118° C. under 18 mm Hg).

Workup

  1. temperaturethe whole is heated
  2. temperatureto reflux for 3 hours
  3. extractionextracted with ethyl acetate
  4. customAfter evaporating
  5. custom11 g of the expected product is recovered

Sources & evidence

ORD record
ord-ca931f9e03e149b4b0900e5cf3985b40
Source dataset
uspto-grants-1993_06
Patent number
US05219873

Reaction notes

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