Methane → N-[2-(4-Carboxymethoxyphenyl)-1-methylethyl]-2-(2-amino-thiazol-4-yl)morpholine dichloride

HRID 1587965Notes

Reaction equation

HRID 1587965 reaction equation
[C:1]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH:14]([N:16]2[CH2:21][CH2:20][O:19][CH:18]([C:22]3[N:23]=[C:24]([NH:27]C(C)=O)[S:25][CH:26]=3)[CH2:17]2)[CH3:15])=[CH:9][CH:8]=1)([O:3]C)=[O:2].[ClH:31].C>>[Cl-:31].[Cl-:31].[C:1]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH:14]([N:16]2[CH2:21][CH2:20][O:19][CH:18]([C:22]3[N:23]=[C:24]([NH2:27])[S:25][CH:26]=3)[CH2:17]2)[CH3:15])=[CH:9][CH:8]=1)([OH:3])=[O:2]

Participants

4

Reactant 3

HCID 297MethaneHCID 313Hydrochloric AcidHCID 19974192N-[2-(4-carbomethoxymethoxyphenyl)1-methylethyl]-2-(2-acetamino-thiazol-4-yl)morpholine

Product 1

HCID 19974372N-[2-(4-Carboxymethoxyphenyl)-1-methylethyl]-2-(2-amino-thiazol-4-yl)morpholine dichloride

Procedure

1.6 g (0.0037 mol) of N-[2-(4-carbomethoxymethoxyphenyl)-1-methylethyl]-2-(2-acetamino-thiazol-4-yl)morpholine in 100 ml of 18% strength hydrochloric acid are heated to reflux under nitrogen for 48 hours. 1.5 g of active charcoal are added to the reaction solution which is throughly stirred and filtered. The solution is then concentrated, and the product is dried in vacuo over potassium hydroxide.

Workup

  1. temperatureto reflux under nitrogen for 48 hours
  2. filtrationfiltered
  3. concentrationThe solution is then concentrated
  4. dry with materialthe product is dried in vacuo over potassium hydroxide

Sources & evidence

ORD record
ord-8149672b8c8d451db721bc5b982987ed
Source dataset
uspto-grants-1993_06
Patent number
US05219852

Reaction notes

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