Hydrochloric Acid → HCID 178479034, compound

HRID 1588042Notes

Reaction equation

HRID 1588042 reaction equation
C(OC([NH:8][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)=O)(C)(C)C.[O:15]1[C:19](=[O:20])[N:18]=[CH:17][NH:16]1.[ClH:21]>C(OCC)(=O)C>[NH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[ClH:21].[O:15]1[C:19](=[O:20])[N:18]=[CH:17][NH:16]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178452706HCID 178452706, compound

Product 1

HCID 178479034HCID 178479034, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
0 °C

Procedure

A solution of ethyl acetate (10 ml) containing 150 mg of 3-(tert-butyloxycarbonylamino)benzene-1,2,4-oxadiazol-5-one was cooled to 0° C. and treated with a continuous stream of hydrogen chloride gas for 10 minutes. The reaction mixture was stirred for 30 minutes more and the solvent and excess hydrogen chloride were removed under reduced pressure. The residue was azeotropically dried with toluene to give 120 mg of the title compound in sufficient purity to continue directly to the next step.

Workup

  1. customthe solvent and excess hydrogen chloride were removed under reduced pressure
  2. dry with materialThe residue was azeotropically dried with toluene

Sources & evidence

ORD record
ord-2cb097703939431998e25a10e5231db8
Source dataset
uspto-grants-1993_06
Patent number
US05220018

Reaction notes

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